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→Input 2
=== Input 2 ===
I like to set Input 2 to Variax(I don't use a Variax - this is a null input). This isn't an issue if you put everything in Channel A for a single amp patch as mentioned above; however, I often run dual amp patches. Input 2: Guitar/Same seems to create a slight phasing effect, which becomes very apparent when running a mono-summing effect such as a Distortion effect before the path split. It also seems to create a louder than expected signal that pushes effects and amps harder than they seem to be designed. For exmample, with Input 1 and 2 set to Guitar, a Screamer effect in front the path split distorts, even at 0% Drive. Or for a Blackface Dbl amp model in front the path split, you will get crossover distortion even at very low Drive settings, sometimes even 0%.
If you have already created single amp patches where you did not put everything in Channel A, try changing Input 2 to Variax (or Mic or some other unused input) and make this a global setting and demo all your patches. You may need to add gain/compression to your earliest effect(s) to get them back to the distortion or compression or volume level you want, but they will likely sound a bit more crisp and responsive.