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→Dual Path Phase Issues
One thing that particularly confused me at first was that certain effects apply a very slight latency to the tone, particularly EQ's and compressors. Putting these in one of the Channels before the mixer but not the other can cause a comb filter effect, cancelling out some high end frequencies or maybe even more. So if you want to put an EQ in Channel A, you may want to put the same EQ in Channel B with neutral settings to avoid the comb filter effect.
I tend to like to use what I can dual cabs - dual amps with the same amp model but different cab/mic settings. The issue is that certain combinations run into the phasing issue. I take advantage of the EQ/compressor latency to resolve this as much as possible. With the right settings, the tone has less of a looseness and phasing to it, and regains crisp high-end. See [[Line_6_Pod_HD_Cab/Mic_Tone#Dual_Cabs_2|here for more info]]. === Sensitive EQ Effects===
Many EQ effects will clip on even a barely hot signal going into them. As mentioned above, I like to keep the VOLUME knob (Ch. Vol.) low to prevent this after my amp block. But it can even occur if they are the first effect in your chain. The Mid-Focus EQ is the worst offender, followed by the Parametric EQ. The Studio EQ is the best.