Changes

I always like to start with using an EQ alone as a boost - it is more transparent and offers more control than most boost pedals. Then you can find where the sweet spots are for your guitar and amp. If you also like the tone of some boost that isn't strictly related to frequency response, try to use it with as neutral settings as possible and use EQ to refine the resulting distortion. Then try it with neutral EQ and use the boost's tone to find the sweet spot. The best settings are probably somewhere in the middle of these two, using both the boost's tone and some EQ refinements.

=== Dirt, Distortion, and Fuzz Pedals ===