The complete signal chain for a typical rig is
:Live/Recording * Hands > Guitar > Pickups > Guitar Electronics > Stomps > Pre-Amp > Effects > Power Amp > Cabinet/Speakers > Microphones > Microphone Pre-Amps > PA/DAW
:Jamming/Practice * Hands > Guitar > Pickups > Guitar Electronics > Stomps > Pre-Amp > Effects > Power Amp > Cabinet/Speakers
Every stage has a significant impact on the tone, and each stage is joined by cables which can also influence the tone.