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→Simple setup for amp with effects loop
This hookup is nearly the same as above, but you run into the effects loop return (power amp in) on the amp. Use "Combo Power Amp" or "Stack Power Amp" output mode (or "Studio/Direct" and make sure you choose "no cab"), and set the line/amp switch to line.
Here you bypass your amp's pre-amp completely, and you use the Pod's amp modeling instead. This gives you a very clean tone - power amps usually don't color the tone very much, at least not until you start really pushing the amp. In that case, you should see the [[Line_6_Pod_HD_Amp/Distortion_Tone#.22Full.22_vs._.22Pre.22|"pre" vs. "full" section on the Amp/Distortion Tone page]] for help in choosing the right amp models for your power amp.
The downside is that you do not have the option to use your amp's pre-amp. If you want that option, you have to use the 4 cable method, described below.