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→Running to an amp ("live")
* The only thing you should ever run your amp's power section output (sometimes labeled "speaker" or "16/8/4 ohm") to is a speaker cabinet or dummy load. Running it to the Pod will fry your amp and your Pod. Running it into nothing will fry your amp.
* You can bypass your amp's pre-amp circuit completely by running a signal into its effects loop return, sometimes labeled "power amp in". This is useful when you never want to use your amp's pre-amp, instead using the Pod's amp simulations.
* By using both your amp's and your Pod's effects loops, you can set up your rig for some patches to use your amp's pre-amp and others to use the Pod's modeling, switching between the two without having to switch any cables. This also lets you place effects in the Pod before and/or after your amp's pre-amp. This is known as [[#4_Cable_Method|the 4 cable method]].
* Some amps have only channel volume knobs, not a final master knob (Peavey ValveKing and 6505 for instance). When running the Pod's output into the effects loop return in these cases, your Pod's MASTER knob will act like a traditional master volume knob on an amp. When using the 4 cable method, for patches that use the amp pre-amp, you should use the channel volume knobs to level the volume equal to your patches where you bypass the amp's pre-amp completely, using the Pod's amp simulations instead.
* Even if you always use your amp's pre-amp for your amp tone, never using the Pod's amp models, you may still prefer to hook up the Pod via the 4 cable method, so that you can position effects before and after the pre-amp, rather than just after.
* The more pieces of gear you have in your signal chain, the more you have to be aware of [[#Gain Staging|gain staging]]. I find it's best to start with everything putting out a low output, and start turning up the outputs on each piece of gear until you are clipping the next one then back off a bit. Your tone will likely start out noisier this way, but I find it's easier to systematically dial in each piece of gear like this than to just turn everything on, find some fuzz or clipping or nastiness in the tone, then start guessing as to where it's coming from.