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→Running to an amp ("live")
Thus, whether your tone is "live" vs. "direct" is patch dependent, and you can switch between the two without having to dig into the system menu to change output modes. The downside to this is that you have to make two versions of all your patches; however, I rarely find that simply switching the output mode produces the same tone live vs. direct. This is especially true if you have a power amp or speakers that add a lot of color to your "live" tone. So I have two versions of all my patches anyway.
The other alternative is to make one version of all your patches and switch output modes for whatever method you are using at the moment. The downside is that for "direct", you have to specify a cab and mic. When you switch the output mode for "live" use, the cab simulation will still be selected and run (see [[#Understanding Output Modes|output modes section]]). Thus, it will be difficult to impossible to dial in a consistent sound between "direct" and "live", and you'll have to make purpose-specific patches anyway. I don’t like using the cab simulation for "live" purposes. It seems to muffle the high end of the tone, which is important for a high gain sound.
As for the actual cable hook-ups, there are a number of ways to do this. I will go from the least optimal/versatile yet simplest to best yet most complex.