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→Running to an amp ("live")
I recommend setting your output mode to the appropriate non-"Studio/Direct" mode. If you want to use your Pod for both "direct" and "live" purposes, I recommend leaving the output mode as "Studio/Direct" and setting your "live" patches up with "no cab" as your cabinet selection. When you use "no cab", you get the same output in every output mode (more-or-less) - all cab/mic simulation is simply disabled.
Thus, whether your tone is "live" vs. "direct" is patch dependent, and you can switch between the two without having to dig into the system menu to change output modes. The downside to this is that you have to make two versions of all your patches; however, I rarely find that simply switching the output mode produces the same tone live vs. direct. This is especially true if you have a power amp or speakers that add a lot of color to your "live" tone. So I have two versions of all my patches anyway.