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(''If you are instead using a full-range amplifier and full-range speakers, even if they are placed in an enclosure designed to look like a guitar amp, or marketed specifically for guitar, I recommend you use [[#Running Direct (PA/board/computer or DAW/monitors/headphones)|direct settings]]; otherwise, the tone will likely be very harsh and trebly.)''
→Running to an amp ("live")
This is for when you are running specifically into a amp and speakers designed for use with guitar. Really, guitar speakers are what really roll off the high frequencies produced by guitar amplifiers or amp models. Guitar power amps also color the tone and may make it warmer, but their coloration is generally much less noticeable than guitar speakers.
I recommend setting your output mode to the appropriate non-"Studio/Direct" mode. If you want to use your Pod for both "direct" and "live" purposes, I recommend leaving the output mode as "Studio/Direct" and setting your "live" patches up with "no cab" as your cabinet selection. When you use "no cab", you get the same output in every output mode (more-or-less) - all cab/mic simulation is simply disabled.