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→Running Direct (PA/board/computer or DAW/monitors/headphones)
You can additionally use effects from the Pod or use external effects, placing them before the Pod or in its effects loop (or even after if you use 1/4" or XLR output).
Running this way generally means you must choose "Studio/Direct" as your output mode, to enable cab/mic simulation (see [[#Output Modes|output modes section]]), unless you are running external speaker simulation (such as an IR). Otherwise, your tone will be very harsh. Even in this case, I still recommend using "Studio/Direct" output mode and using the "no cab" option for your cabinet selection, simply to reduce complication.
However I should point out that you can use the cab models with a non-"Studio/Direct" output mode as a mild EQ effect, and it will sound relatively natural with an external speaker simulator/IR. I don’t recommend this, as it seems to dial out some of the high end, which is the area most difficult to dial in with the Pod; but it may be fruitful to experiment with if you don't mind losing some highs.