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* Guitar > [external effects >] Pod guitar in * [Pod effects loop out > external effects > Pod effects loop return] * Pod unbalanced out > [external effects >] Amp effects loop return (power amp in)
→Simple setup for amp with effects loop
The downside is that you do not have the option to use your amp's pre-amp. If you want that option, you have to use the 4 cable method, described below.
This is how I run the Pod to my Spider Valve combo.